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This paper presents a computational framework for modeling biobehavioral rhythms - the repeating cycles of physiological, psychological, social, and environmental events - from mobile and wearable data streams. The framework incorporates four main components: mobile data processing, rhythm discovery, rhythm modeling, and machine learning. We evaluate the framework with two case studies using datasets of smartphone, Fitbit, and OURA smart ring to evaluate the framework’s ability to (1) detect cyclic biobehavior, (2) model commonality and differences in rhythms of human participants in the sample datasets, and (3) predict their health and readiness status using models of biobehavioral rhythms. Our evaluation demonstrates the framework’s ability to generate new knowledge and findings through rigorous micro- and macro-level modeling of human rhythms from mobile and wearable data streams collected in the wild and using them to assess and predict different life and health outcomes.